Audience and Lecturer

Publications

 

Antifungal

 

  1. Ravichandran A, Escano J, Lee JH, Ross MK, Austin F, Orugunty R, Lu SE, Smith L. (2020) Formulation, Pharmacological Evaluation, and Efficacy Studies of Occidiofungin, a Novel Antifungal. Antimicrob Agents Chemother. 17;64(12):e01737-20. doi: 10.1128/AAC.01737-20. PMID: 32958713; PMCID: PMC7674058.

  2. Ravichandran, A, Hull, K, Romo, D, Lu, SE, Albee, A, Nutter, C, Gordon, D, Ghannoum, M, Lockless, S, and Smith, L. (2019) A Novel Actin Binding Drug with In Vivo Efficacy. Antimicrob Agents Chemother 63:e01585-18. https://doi.org/10.1128/AAC.01585-18.

  3. Emrick D, Ravichandran A, Gosai J, Lu S, Gordon DM, Smith L. The antifungal occidiofungin triggers an apoptotic mechanism of cell death in yeast. J Nat Prod. 2013 May 24;76(5):829-38. doi: 10.1021/np300678e. Epub 2013 May 14. PubMed PMID: 23672235.

  4. Ravichandran A, Gu G, Escano J, Lu S, and Smith L. Served with a twist, Nature Chemical Biology 9:215 (2013) Research Highlight-Biosynthesis.

  5. Ellis D, Gosai J, Emrick C, Heintz R, Romans L, Gordon D, Lu SE, Austin F, Smith L. Occidiofungin's chemical stability and in vitro potency against Candida species. Antimicrob Agents Chemother. 2012 Feb;56(2):765-9. doi: 10.1128/AAC.05231-11. Epub 2011 Nov 21. PubMed PMID: 22106210; PubMed Central PMCID: PMC3264235.

  6. Gu G, Smith L, Liu A, Lu SE. Genetic and biochemical map for the biosynthesis of occidiofungin, an antifungal produced by Burkholderia contaminans strain MS14. Appl Environ Microbiol. 2011 Sep;77(17):6189-98. doi: 10.1128/AEM.00377-11. Epub 2011 Jul 8. PubMed PMID: 21742901; PubMed Central PMCID: PMC3165383.

  7. Lu SE, Novak J, Austin FW, Gu G, Ellis D, Kirk M, Wilson-Stanford S, Tonelli M, Smith L. Occidiofungin, a unique antifungal glycopeptide produced by a strain of Burkholderia contaminans. Biochemistry. 2009 Sep 8;48(35):8312-21. doi: 10.1021/bi900814c. PubMed PMID: 19673482; PubMed Central PMCID: PMC2771368.

  8. Foxfire A, Buhrow AR, Orugunty RS, Smith L. (2021) Drug discovery through the isolation of natural products from Burkholderia. Expert Opin Drug Discov. doi: 10.1080/17460441.2021.1877655. Epub ahead of print. PMID: 33467922.

 

Antibacterial

  1. Geng M, Ravichandran A, Escano J, and Smith L. (2018) Efficacious Analogs of the Lantibiotic Mutacin 1140 against a Systemic Methicillin-Resistant Staphylococcus aureus Infection. Antimicrob Agents Chemother. 62:e01626-18. https://doi.org/10.1128/AAC.01626-18.

  2. Geng M, Smith L. (2018) Modifying the lantibiotic mutacin 1140 for increased yield, activity and stability. Appl Environ Microbiol. 84:e00830-18. https://doi.org/10.1128/AEM.00830

  3. Geng M, Smith L.  (2018) Improving the attrition rate of Lanthipeptide discovery for commercial applications. Expert Opin Drug Discov. 13(2):155-167. doi: 10.1080/17460441.2018.1410137. Epub 2017 Dec 1. PubMed PMID: 29195488.

  4. Geng M, Smith L. (2018) Modifying the lantibiotic mutacin 1140 for increased yield, activity and stability. Appl Environ Microbiol. May 18. pii: AEM.00830-18. doi: 10.1128/AEM. 00830-18. [Epub ahead of print]

  5. Geng M, Smith L. (2018) Improving the attrition rate of Lanthipeptide discovery for commercial applications. Expert Opin Drug Discov. Feb;13(2):155-167. doi: 10.1080/17460441.2018.1410137. PubMed PMID: 29195488.

  6. Escano J, Ravichandran A, Salamat B, Smith L. (2017) Carboxyl Analogue of Mutacin 1140, a Scaffold for Lead Antibacterial Discovery. Appl Environ Microbiol. Jun 30;83(14). pii: e00668-17. doi: 10.1128/AEM.00668-17. Print 2017 Jul 15. PubMed PMID: 28500042; PubMed Central PMCID: PMC5494638. SPOTLIGHT - article was featured by the journal.

  7. Escano J, Smith L. Multipronged approach for engineering novel peptide analogues of existing lantibiotics. Expert Opin Drug Discov. 2015;10(8):857-70. doi: 10.1517/17460441.2015.1049527. Epub 2015 May 23. Review. PubMed PMID: 26004576.

  8. Emrick D, Ravichandran A, Gosai J, Lu S, Gordon DM, Smith L. The antifungal occidiofungin triggers an apoptotic mechanism of cell death in yeast. J Nat Prod. 2013 May 24;76(5):829-38. doi: 10.1021/np300678e. Epub 2013 May 14. PubMed PMID: 23672235.

 

Anticancer

  1. Lai Hing S, Ravichandran A, Escano J, Cooley J, Austin F, Smith L. Toxicological Evaluation of Occidiofungin against Mice and Human Cancer Cell Lines. Pharmacology & Pharmacy, 5, 1085-1093. (2014). 2014 October; 5:1085-1093.

  2. Foxfire A, Buhrow AR, Orugunty RS, Smith L. (2021) Drug discovery through the isolation of natural products from Burkholderia. Expert Opin Drug Discov. doi: 10.1080/17460441.2021.1877655. Epub ahead of print. PMID: 33467922.

 

Contact Us

Sano Chemicals Inc.

905 Innovation Drive

Bryan, Texas 77808

Email: info@sanochemicals.com

Tel: 855-384-7266 (Sano)

Fax: 866-438-4013

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